DefEYEing Convention in Ocular Surface Disease & Ocular Surgery

Illustration of BIOVANCE® 3L Ocular triple-layer decellularized basement membrane for ocular surface surgery.
Illustration of BIOVANCE® 3L Ocular triple-layer decellularized basement membrane for ocular surface surgery.
BIOVANCE® 3L OCULAR logo

The only decellularized
basement membrane (DBM)1

Take the next step with BIOVANCE 3L Ocular

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Tri-layer architecture with a preserved natural epithelial basement membrane and intact extracellular matrix (ECM) structure1

BIOVANCE 3L Ocular membrane held with forceps
  • Cut and assembled as a unique laminated tri-layer design1
  • Stromal side of basement membrane faces out on both sides of the scaffold2
    • Ensures appropriate interface with the ocular surface, regardless of scaffold orientation1

BIOVANCE 3L Ocular’s three-layer design enhances its handling properties, without the need for a ring2

BIOVANCE 3L Ocular membrane held with forceps
Diagram showing BIOVANCE 3L Ocular with three stacked decellularized basement membrane layers.
Diagram showing BIOVANCE 3L Ocular with three stacked decellularized basement membrane layers.
Diagram of BIOVANCE single-layer decellularized basement membrane.

Practical benefits for surgeons and patients 

  • Storage at ambient room temperature1
  • No specific orientation (which side is up or down) required, allowing ease of handling1
  • Does not contain a symblepharon ring, which may be associated with eye pain, headache, and discomfort1,3
  • Aseptically processed and terminally sterilized with E-beam irradiation1
  • Tested post-sterilization to demonstrate the absence of bacterial and fungal pathogens1

Practical benefits for surgeons and patients 

  • Storage at ambient room temperature1
  • No specific orientation (which side is up or down) required, allowing ease of handling1
  • Does not contain a symblepharon ring, which may be associated with eye pain, headache, and discomfort1,3
  • Aseptically processed and terminally sterilized with E-beam irradiation1
  • Tested post-sterilization to demonstrate the absence of bacterial and fungal pathogens1

Available in 6 convenient shapes & sizes1

Graphic showing the six available BIOVANCE membrane sizes
Graphic showing the six available BIOVANCE membrane sizes

OR, operating room.

Not actual size.

Review our product brochure to learn more about the only decellularized basement membranes

Download

BIOVANCE 3L Ocular:

Proven performance across corneal pathologies

Stronger adhesion. Greater proliferation.2,4

An in vitro test was conducted to measure viability, adhesion, and proliferation of human corneal and conjunctival epithelial cells at days 1, 4, and 7.

Explore a peer-reviewed journal article comparing BIOVANCE 3L Ocular performance with conventional approaches 

Download

Simple and intuitive application process1

Incorporate BIOVANCE 3L Ocular into your practice to manage the full spectrum of ocular surface diseases

1. Prepare

2. Place

3. Patch

Real-world clinical videos featuring BIOVANCE 3L Ocular 

See BIOVANCE 3L Ocular in action

Ocular surface diseases or epithelial defects

Ocular surface diseases or epithelial defects

Close-up image of an eye during ocular surgery, with a metal surgical instrument and suction device applied to the exposed white scleral tissue.

Sutureless, glueless pterygium surgery

Access support

Verification of coverage and explanation of insurance benefits

Coding and billing assistance

Facilitation of prior authorization or 
pre-certification

Onboarding call and education

Appeal assistance after insurance denial

INDICATIONS FOR USE

BIOVANCE 3L Ocular is an allograft intended for use as a biological membrane covering that provides an extracellular matrix. As a barrier membrane, BIOVANCE 3L Ocular is intended to protect the underlying tissue and preserve tissue plane boundaries. Applications include, but are not limited to, corneal and conjunctival related injuries or defects such as corneal epithelial defects, pterygium repair, fornix reconstruction, and other procedures.

IMPORTANT SAFETY INFORMATION

BIOVANCE 3L Ocular is contraindicated in patients with a known hypersensitivity to BIOVANCE 3L Ocular. If a patient has an adverse reaction related to the use of BIOVANCE 3L Ocular, immediately discontinue its use. BIOVANCE 3L Ocular should not be used on clinically infected wounds. The pouch contents are sterile if the pouch is unopened and undamaged. Do not use if package seal is broken. Discard the material if mishandling has caused possible damage or contamination. Do not resterilize. BIOVANCE 3L Ocular must be used prior to the expiration date on the product pouch. BIOVANCE 3L Ocular should not be used together with a collagenase product on the wound.

For product information, contact 786-723-7178 or email info@defeye.com. For adverse reaction reporting, contact 844-963-2273. Please refer to the BIOVANCE 3L Ocular package insert for complete product information.

References: 1. BIOVANCE 3L Ocular. Package insert. 2. Mao Y, Protzman NM, John N, et al. An in vitro comparison of human corneal epithelial cell activity and inflammatory response on differently designed ocular amniotic membranes and a clinical case study. J Biomed Mater Res B Appl Biomater. 2023;111(3):684-700. 3. Pachigolla G, Prasher P, Di Pascuale MA, McCulley JP, McHenry JG, Mootha VV. Evaluation of the role of ProKera in the management of ocular surface and orbital disorders. Eye Contact Lens. 2009;35(4):172-175. 4. Data on file. DefEYE Ophthalmics, Inc.

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